Of the ER and reduces testosterone

Enclomifene (INNTooltip International Nonproprietary Name), or enclomiphene (USANTooltip United States Adopted Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and hence gonadal production of testosterone. It is one of the two stereoisomers of clomifene, which itself is a mixture of 38% zuclomifene and 62% enclomifene. Enclomifene is the (E)-stereoisomer of clomifene, while zuclomifene is the (Z)-stereoisomer. Whereas zuclomifene is more estrogenic, enclomifene is more antiestrogenic. In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the ER and reduces testosterone levels in men. As such, isomerically pure enclomifene is more favorable than clomifene as a progonadotropin for the treatment of male hypogonadism.

Double Cross Purposes is a 1937 mystery detective novel by the British author Ronald Knox. It is the fifth and last in his series of novels featuring the insurance investigator Miles Bredon, one of the Golden Age Detectives. Like the previous novel it takes place in Scotland. It features several characters who appeared in earlier novels, including the schoolmaster Edward Pulteney whose skills at fishing come in useful to Bredon. While Knox continued to write prolifically for many years, this remained his last novel in the detective genre.